Expression of an aromatic-dependent decarboxylase which provides growth-essential CO2 equivalents for the acetogenic (Wood) pathway of Clostridium thermoaceticum

@article{Hsu1990ExpressionOA,
  title={Expression of an aromatic-dependent decarboxylase which provides growth-essential CO2 equivalents for the acetogenic (Wood) pathway of Clostridium thermoaceticum},
  author={Todd Hsu and Mathias Lux and Harold L Drake},
  journal={Journal of Bacteriology},
  year={1990},
  volume={172},
  pages={5901 - 5907}
}
The acetogen Clostridium thermoaceticum generates growth-essential CO2 equivalents from carboxylated aromatic compounds (e.g., 4-hydroxybenzoate), and these CO2 equivalents are likely integrated into the acetogenic pathway (T. Hsu, S. L. Daniel, M. F. Lux, and H. L. Drake, J. Bacteriol. 172:212-217, 1990). By using 4-hydroxybenzoate as a model substrate, an assay was developed to study the expression and activity of the decarboxylase involved in the activation of aromatic carboxyl groups. The… 
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TLDR
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TLDR
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Findings demonstrate that C. thermoaceticum is competent in the decarboxylation of certain aromatic compounds and under certain conditions, decar boxylation may be integrated to the flow of carbon and energy during acetogenesis.
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