Expression of an N-methyl-D-aspartate-type receptor by human and rat osteoblasts and osteoclasts suggests a novel glutamate signaling pathway in bone.

@article{Patton1998ExpressionOA,
  title={Expression of an N-methyl-D-aspartate-type receptor by human and rat osteoblasts and osteoclasts suggests a novel glutamate signaling pathway in bone.},
  author={A. J. Patton and P. Genever and M. Birch and L. Suva and T. Skerry},
  journal={Bone},
  year={1998},
  volume={22 6},
  pages={
          645-9
        }
}
  • A. J. Patton, P. Genever, +2 authors T. Skerry
  • Published 1998
  • Biology, Medicine
  • Bone
  • Signaling between the various types of cells found in bone is responsible for controlling the activity of osteoblasts and osteoclasts, and therefore the regulation of bone mass. Our identification of a neuronal glutamate transporter in osteoblasts and osteocytes suggests the possibility that bone cells may use the excitatory amino acid glutamate as a signaling molecule. In these studies we report the expression of different subtypes of glutamate receptors in osteoblasts and osteoclasts in vitro… CONTINUE READING
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    References

    SHOWING 1-10 OF 21 REFERENCES
    Expression and role of ionotropic glutamate receptors in pancreatic islet cells
    • N. Inagaki, H. Kuromi, +6 authors S. Seino
    • Chemistry, Medicine
    • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
    • 1995
    • 190
    Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate transporter from rat brain.
    • 1,165
    • PDF
    PTH/PTHrP receptor expression on osteoblasts and osteocytes but not resorbing bone surfaces in growing rats
    • B. Fermor, T. Skerry
    • Chemistry, Medicine
    • Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
    • 1995
    • 122
    Cloned glutamate receptors.
    • 3,937
    Localization of [3H]glutamate binding sites in rat adrenal medulla
    • 78
    Glutamate receptors of the N-methyl-D-aspartate subtype in the myenteric plexus of the guinea pig ileum.
    • 96