• DOI:10.1016/S8756-3282(98)00061-1
Corpus ID: 21457383

Expression of an N-methyl-D-aspartate-type receptor by human and rat osteoblasts and osteoclasts suggests a novel glutamate signaling pathway in bone.

@article{Patton1998ExpressionOA,
  title={Expression of an N-methyl-D-aspartate-type receptor by human and rat osteoblasts and osteoclasts suggests a novel glutamate signaling pathway in bone.},
  author={A. J. Patton and P. Genever and M. Birch and L. Suva and T. Skerry},
  journal={Bone},
  year={1998},
  volume={22 6},
  pages={
          645-9
        }
}

A. J. Patton, P. Genever, +2 authors T. Skerry

Published 1998

Biology, Medicine

Bone

Signaling between the various types of cells found in bone is responsible for controlling the activity of osteoblasts and osteoclasts, and therefore the regulation of bone mass. Our identification of a neuronal glutamate transporter in osteoblasts and osteocytes suggests the possibility that bone cells may use the excitatory amino acid glutamate as a signaling molecule. In these studies we report the expression of different subtypes of glutamate receptors in osteoblasts and osteoclasts in vitro… CONTINUE READING

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