Expression of an Idiotype (id-460) during in Vivo Anti-dinitrophenyl Antibody Responses I. Mapping of Genes for Id-460 Expression to the Variable Region of Immunoglobulin Heavy-chain Locus and to the Variable Region of Immunoglobulin K-light-chain Locus

Abstract

Unique antigenic determinants found on antibodies of a part icular specificity are called idiotypes (Id); inbred mouse strains have been shown to inherit the ability to express a particular Id during responses to the same antigen in a reproducible manner. In general, these studies have shown that the genes controlling the expression of an Id are linked to the immunoglobul in heavy-chain gene complex (Ig-H). 1 Where crossing over between the genes coding for constant portion of the Ig-H complex (CH) and variable portion of the Ig-H complex (VH) have occurred, the Id is inherited in linkage with V H (i). More recently, light-chain polymorphisms have been described, and these genes have also been demonstrated to affect the expression of the Id (2, 3). One of these polymorphisms is located in the genes of variable region of immunogobulin ~¢-light chains (VJ¢) (2, 4). This was first detected by tryptic peptide mapping of cysteine-containing peptides from VK by Edelman and Gottlieb (4), and it was subsequently demonstrated to be linked to a genetic locus on chromosome 6 that controls the T cell differentiation antigen Lyt-3.1 (5). Studies by Claflin et al. (6) and by Gibson (7) have defined similar K-chain polymorphisms. Mice of strains that bear the Lyt-3.1 allele (AKR, C58, PL, and RF) express one pat tern of Vtc-gene products, whereas all Lyt-3.2 strains express a different pattern. More recently, Gibson and MacLean (8) have detected an electrophoretic difference bewteen certain K-light

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@inproceedings{Dzierzak1980ExpressionOA, title={Expression of an Idiotype (id-460) during in Vivo Anti-dinitrophenyl Antibody Responses I. Mapping of Genes for Id-460 Expression to the Variable Region of Immunoglobulin Heavy-chain Locus and to the Variable Region of Immunoglobulin K-light-chain Locus}, author={Elaine Dzierzak and Charles A . Janeway and Paul D. Gottlieb}, year={1980} }