Expression of an Escherichia coli antigenic fusion protein comprising the heat labile toxin B subunit and the heat stable toxin, and its assembly as a functional oligomer in transplastomic tobacco plants.

@article{RosalesMendoza2009ExpressionOA,
  title={Expression of an Escherichia coli antigenic fusion protein comprising the heat labile toxin B subunit and the heat stable toxin, and its assembly as a functional oligomer in transplastomic tobacco plants.},
  author={Sergio Rosales-Mendoza and Angel Gabriel Alpuche-Sol{\'i}s and Ruth E. Soria-Guerra and Leticia Moreno-Fierros and Luzmila Mart{\'i}nez-Gonz{\'a}lez and Areli Herrera-D{\'i}az and Schuyler S. Korban},
  journal={The Plant journal : for cell and molecular biology},
  year={2009},
  volume={57 1},
  pages={45-54}
}
Enterotoxigenic Escherichia coli (ETEC) strains are important pathogens in developing countries. Some vaccine formulations containing the heat labile toxin B subunit (LTB) have been used in clinical trials; however, the induction of neutralizing antibodies against the heat-stable toxin (ST), a poor immunogenic peptide, is necessary, as most ETEC strains can produce both toxins. In this study, a plant optimized synthetic gene encoding for the LTB-ST fusion protein has been introduced into… CONTINUE READING
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