Expression of alternative oxidase in Drosophila ameliorates diverse phenotypes due to cytochrome oxidase deficiency

@inproceedings{Kemppainen2014ExpressionOA,
  title={Expression of alternative oxidase in Drosophila ameliorates diverse phenotypes due to cytochrome oxidase deficiency},
  author={Kia K. Kemppainen and Juho Rinne and Ashwin Sriram and Matti Lakanmaa and Akbar Zeb and Tea Tuomela and Anna R Popplestone and Satpal Singh and Alberto Hernando Sanz and Pierre Rustin and Howard T. Jacobs},
  booktitle={Human molecular genetics},
  year={2014}
}
Mitochondrial dysfunction is a significant factor in human disease, ranging from systemic disorders of childhood to cardiomyopathy, ischaemia and neurodegeneration. Cytochrome oxidase, the terminal enzyme of the mitochondrial respiratory chain, is a frequent target. Lower eukaryotes possess alternative respiratory-chain enzymes that provide non-proton-translocating bypasses for respiratory complexes I (single-subunit reduced nicotinamide adenine dinucleotide dehydrogenases, e.g. Ndi1 from yeast… CONTINUE READING
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