• Biology
  • Published 1997

Expression of adenoviral E3 transgenes in b cells prevents autoimmune diabetes (insulin-dependent diabetes mellitusylymphocytic choriomeningitis virusymajor histocompatibility complex expression)

@inproceedings{Herrath1997ExpressionOA,
  title={Expression of adenoviral E3 transgenes in b cells prevents autoimmune diabetes (insulin-dependent diabetes mellitusylymphocytic choriomeningitis virusymajor histocompatibility complex expression)},
  author={Matthias G. von Herrath and Shimon Efrat and B. A. Oldstone and Marshall S Horwitz},
  year={1997}
}
The adenovirus (Ad) genome contains im- munoregulatory and cytokine inhibitory genes that are pre- sumed to function in facilitating acute infection or in estab- lishing persistence in vivo. Some of these genes are clustered in early region 3 (E3), which contains a 19-kDa glycoprotein (gp19) that inhibits the transport of selected class I major histocompatibility complex (MHC) molecules out of the en- doplasmic reticulum. In addition, the E3 region contains three protein inhibitors of the… CONTINUE READING

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Adenovirus E3 MHC inhibitory genes but not TNF/Fas apoptotic inhibitory genes expressed in beta cells prevent autoimmune diabetes.

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