Expression of activated rat neu oncogene is sufficient to induce experimental metastasis in 3T3 cells.

@article{Yu1991ExpressionOA,
  title={Expression of activated rat neu oncogene is sufficient to induce experimental metastasis in 3T3 cells.},
  author={Dihua Yu and M C Hung},
  journal={Oncogene},
  year={1991},
  volume={6 11},
  pages={1991-6}
}
Amplification or overexpression of the human neu oncogene has been shown to correlate with the number of lymph node metastases in breast cancer patients, suggesting that expression of the neu oncogene may be associated with increased metastatic potential. However, there has been no systematic study on the role of the neu oncogene in metastasis to support this correlation. In our study, mouse embryo fibroblast 3T3 cells transformed by the mutation-activated rat neu oncogene exhibited metastatic… CONTINUE READING

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