Expression of acetoacetyl-CoA synthetase, a novel cytosolic ketone body-utilizing enzyme, in human brain.

@article{Ohgami2003ExpressionOA,
  title={Expression of acetoacetyl-CoA synthetase, a novel cytosolic ketone body-utilizing enzyme, in human brain.},
  author={Masahiro Ohgami and Noriko Takahashi and Masahiro Yamasaki and Tetsuya Fukui},
  journal={Biochemical pharmacology},
  year={2003},
  volume={65 6},
  pages={989-94}
}
Acetoacetyl-CoA synthetase (AACS, acetoacetate-CoA ligase, EC 6.2.1.16) is a ketone body-utilizing enzyme, the physiological role of which remains unclear yet in mammals, particularly has never been studied in human. In order to investigate the tissue distribution of AACS in human, cDNA encoding AACS was isolated from HepG2 cells. Amino acid sequence of human AACS deduced from the open reading frame showed high homology (89.3%) with that of rat AACS and much less homology (43.7%) with that of… CONTINUE READING

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