Expression of a transformation-related protein (p53) in the malignant stage of Friend virus-induced diseases.

Abstract

Stage 1 (pre-malignant) and stage 2 (malignant) cells derived from mice infected with Friend murine leukemia virus or polycythemia-inducing Friend virus complex were examined and compared for the expression of a transformation-related cellular protein, p53. Stage 2 cells were found to express high levels of p53, whereas stage 1 cells did not express detectable levels of this protein. These results indicate that p53 may be a marker for transformed cells present in the second stage of diseases induced by Friend murine leukemia virus or polycythemia-inducing Friend virus complex.

Cite this paper

@article{Ruscetti1983ExpressionOA, title={Expression of a transformation-related protein (p53) in the malignant stage of Friend virus-induced diseases.}, author={Sandra K. Ruscetti and Edward M . Scolnick}, journal={Journal of virology}, year={1983}, volume={46 3}, pages={1022-6} }