Expression of a sonic hedgehog signal transducer, hedgehog-interacting protein, by human basal cell carcinoma.


BACKGROUND Aberrant activation of the hedgehog pathway has been identified in various human tumours, including familial and sporadic basal cell carcinomas (BCCs). It has been postulated that binding of sonic hedgehog protein (SHH) to its receptor, patched protein (PTC), releases the inhibitory effect of PTC against smoothened protein (SMO), another protein… (More)