Expression of a single transfected cDNA converts fibroblasts to myoblasts

@article{Davis1987ExpressionOA,
  title={Expression of a single transfected cDNA converts fibroblasts to myoblasts},
  author={R. L. Davis and H. Weintraub and A. Lassar},
  journal={Cell},
  year={1987},
  volume={51},
  pages={987-1000}
}
5-azacytidine treatment of mouse C3H10T1/2 embryonic fibroblasts converts them to myoblasts at a frequency suggesting alteration of one or only a few closely linked regulatory loci. Assuming such loci to be differentially expressed as poly(A)+ RNA in proliferating myoblasts, we prepared proliferating myoblast-specific, subtracted cDNA probes to screen a myocyte cDNA library. Based on a number of criteria, three cDNAs were selected and characterized. We show that expression of one of these cDNAs… Expand
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Positive autoregulation of the myogenic determination gene MyoD1
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