Expression of a single-chain human interleukin-12 gene in transgenic tobacco plants and functional studies.

@article{GutirrezOrtega2004ExpressionOA,
  title={Expression of a single-chain human interleukin-12 gene in transgenic tobacco plants and functional studies.},
  author={Abel Guti{\'e}rrez-Ortega and Federico {\'A}vila-Moreno and Luis Jorge Saucedo-Arias and Carmen Sanchez-Torres and Miguel Angel G{\'o}mez-Lim},
  journal={Biotechnology and bioengineering},
  year={2004},
  volume={85 7},
  pages={
          734-40
        }
}
Interleukin 12 (IL-12) is a key heterodimeric cytokine produced by a variety of antigen-presenting cells, including dendritic cells, macrophages, and B cells. It displays a potent array of biological activities affecting natural killer (NK) and T cells. These activities include promotion of cell-mediated or type 1 T helper cell responses (Th1). Due to that property, IL-12 has been employed in cancer immunotherapy, in mouse models of infectious diseases and in airway inflammation, and it may… CONTINUE READING
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