Expression of a p53 mutant in the epidermis of transgenic mice accelerates chemical carcinogenesis

Abstract

To develop an in vivo model for studying the role of the p53 tumor suppressor in skin carcinogenesis, a murine p53172H mutant (equivalent to human p53175H) was expressed in the epidermis of transgenic mice, utilizing a targeting vector based on the human keratin 1 gene (HK1.p53m). HK1.p53m mice developed normally and did not exhibit an obvious epidermal… (More)
DOI: 10.1038/sj.onc.1201890

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