Expression of a novel type of immunoglobulin C lambda transcripts in human mature B lymphocytes producing kappa light chains.

Abstract

Ordered rearrangement of immunoglobulin genes (heavy chain then kappa and eventually lambda genes) is observed during B lymphocyte ontogeny. Unexpectedly, we found that human mature B cells producing kappa chains and having germ-line lambda genes contain lambda mRNA consisting of an invariant 5' region (herein termed X) and of one of the classical C lambda… (More)

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