Expression of a novel splice variant of human mGluR1 in the cerebellum

  title={Expression of a novel splice variant of human mGluR1 in the cerebellum},
  author={Andrew J. Makoff and T. Phillips and C Pilling and Piers C. Emson},
WE have isolated clones of a novel splice variant of metabotropic glutamate receptor type 1 (mGluR1) from a human cerebellum cDNA library. Translation of this variant, mGluR1g would result in the addition of just one amino acid after the exon/intron boundary where the other splice variants diverge. RNA dot blot analysis using an mGluR1g-specific probe demonstrated expression in the cerebellum and also high levels in the kidney. Northern blotting using the same probe showed expression of a 4 κB… 
Cloning of novel splice variants of mouse mGluR1.
Phylogeny and expression divergence of metabotropic glutamate receptor genes in the brain of zebrafish (Danio rerio)
Group I mglurs are similarly expressed in brain areas of both larval and adult zebrafish, suggesting that their functions are comparable during these stages, and expression pattern of paralogs generated by the teleost‐specific whole genome duplication is overlapping in some brain regions but complementary in others, suggesting sub‐ and/or neofunctionalization in the latter.
Metabotropic glutamate receptors in the cerebellum with a focus on their function in Purkinje cells
The mechanism underlying the mGLUR1-mediated postsynaptic current as well as current theories on the role of mGluR1 in parallel fiber-Purkinje cell long-term depression are discussed.
7TM receptors: the splicing on the cake.
Evolutionary conservation of alternative splicing in chicken
Comparing chicken and mammalian transcript sequences of 41 alternatively-spliced genes and 50 frequently accessed genes shows a high frequency of splicing events in chicken, similar to that observed in mammals.
Metabotropic Glutamate 1 Receptor: Current Concepts and Perspectives
Recent advancements in the pharmacology and concepts about the intracellular transduction and pathophysiological role of mGlu1 receptors are discussed and earlier data is reviewed in view of these novel findings.
International Union of Basic and Clinical Pharmacology. CXI. Pharmacology, Signaling, and Physiology of Metabotropic Glutamate Receptors
The physiologic and pathophysiological roles for individual mGlu receptor subtypes including the pleiotropic nature of intracellular signal transduction arising from each are reviewed and emerging areas that are offering new avenues to selectively modulate neurotransmission are highlighted.


A novel metabotropic glutamate receptor expressed in the retina and olfactory bulb
The pharmacology and expression of mGluR8 in mitral/tufted cells suggest it could be a presynaptic receptor modulating glutamate release by these cells at their axon terminals in the entorhinal cortex.
Molecular diversity of glutamate receptors and implications for brain function.
The molecular and functional diversity of the glutamate receptors is reviewed and their implications for integrative brain function are discussed.
Faull for the human brain tissue, Mr H. Spence for oligonucleotide synthesis, Mr M. Oxer and Mr I. Allen for DNA sequencing. This work was supported in part by an MRC/Glaxo
  • Neuron 14,
  • 1995