Expression of a novel aristaless related homeobox gene ‘Arx’ in the vertebrate telencephalon, diencephalon and floor plate

@article{Miura1997ExpressionOA,
  title={Expression of a novel aristaless related homeobox gene ‘Arx’ in the vertebrate telencephalon, diencephalon and floor plate},
  author={Hirohito Miura and Masako Yanazawa and Kentaro Kato and Kunio Kitamura},
  journal={Mechanisms of Development},
  year={1997},
  volume={65},
  pages={99-109}
}
We have isolated a novel homeobox gene that is expressed in the vertebrate central nervous system and which shows striking similarity to the Drosophila al gene in the homeodomain (85% identity) and in a 17 amino acid-sequence near the carboxyl-terminus. This gene was designated Arx (aristaless related homeobox gene) in consideration of its structural similarity to the al gene. Arx was highly conserved between mouse and zebrafish. Neuromeric expression in the forebrain and longitudinal… CONTINUE READING

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