Expression of a new mutation (Axd) causing axial defects in mice correlates with maternal phenotype and age.

@article{Essien1990ExpressionOA,
  title={Expression of a new mutation (Axd) causing axial defects in mice correlates with maternal phenotype and age.},
  author={Francine B. Essien and M. B. Haviland and A E Naidoff},
  journal={Teratology},
  year={1990},
  volume={42 2},
  pages={183-94}
}
A new autosomal mutation, Axd (axial defects), is described. Axd segregates in a simple Mendelian fashion, and it is dominant with incomplete penetrance and variable expressivity. The phenotype of Axd heterozygotes ranges from a variety of tail anomalies to visibly normal tails. Approximately 12% of neonates from curly-tail (CT) F1 (Axd/+) x F1 (Axd/+) matings exhibit open neural tube defects (NTD) in the lumbosacral region and 16% have curly tails. Mean litter sizes and resorption rates… CONTINUE READING