Expression of a new disialyllacto structure in the lipopolysaccharide of non-typeable Haemophilus influenzae.

@article{Twelkmeyer2011ExpressionOA,
  title={Expression of a new disialyllacto structure in the lipopolysaccharide of non-typeable Haemophilus influenzae.},
  author={Brigitte Twelkmeyer and Peter K Burstr{\"o}m and Jianjun Li and E Richard Moxon and Derek W Hood and Elke K. H. Schweda},
  journal={Carbohydrate research},
  year={2011},
  volume={346 13},
  pages={
          1885-97
        }
}
The structure of lipopolysaccharide (LPS) expressed by non-typeable Haemophilus influenzae (NTHi) strains 1008 and 1247 has been investigated by mass spectrometry and NMR analyses on O-deacylated LPS and core oligosaccharide material. Both strains express the conserved triheptosyl inner core, [l-α-d-Hepp-(1→2)-[PEtn→6]-l-α-d-Hepp-(1→3)-l-α-d-Hepp-(1→5)-[PPEtn→4]-α-Kdo-(2→6)-Lipid A] with PCho→6)-β-d-Glcp (GlcI) substituting the proximal heptose (HepI) at O-4. Strain 1247 expresses the common… 
1 Citations
Diversity-oriented synthesis of inner core oligosaccharides of the lipopolysaccharide of pathogenic Gram-negative bacteria.
TLDR
This work synthesized a range of LPS inner core oligosaccharides from a variety of pathogenic bacteria including Y. pestis, H. influenzae, and Proteus that cause plague, meningitis, and severe wound infections and explored their antigenic and immunogenic properties as well as potential applications such as diagnostic tools and vaccines.

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