Expression of a naturally occurring angiotensin AT(1) receptor cleavage fragment elicits caspase-activation and apoptosis.

@article{Cook2011ExpressionOA,
  title={Expression of a naturally occurring angiotensin AT(1) receptor cleavage fragment elicits caspase-activation and apoptosis.},
  author={Julia L. Cook and Akannsha Singh and Dawn Deharo and Jawed Alam and Richard N. Re},
  journal={American journal of physiology. Cell physiology},
  year={2011},
  volume={301 5},
  pages={C1175-85}
}
Several transmembrane receptors are documented to accumulate in nuclei, some as holoreceptors and others as cleaved receptor products. Our prior studies indicate that a population of the 7-transmembrane angiotensin type-1 receptor (AT(1)R) is cleaved in a ligand-augmented manner after which the cytoplasmic, carboxy-terminal cleavage fragment (CF) traffics… CONTINUE READING