Expression of a natural tumor antigen by thymic epithelial cells impairs the tumor-protective CD4+ T-cell repertoire.

@article{Bos2005ExpressionOA,
  title={Expression of a natural tumor antigen by thymic epithelial cells impairs the tumor-protective CD4+ T-cell repertoire.},
  author={Rinke Bos and Suzanne van Duikeren and Thorbald van Hall and Patricia Kaaijk and R Dieter Taubert and Bruno Kyewski and Ludger Klein and Cornelis J. M. Melief and Rienk Offringa},
  journal={Cancer research},
  year={2005},
  volume={65 14},
  pages={6443-9}
}
A variety of antigens that display a highly tissue-specific expression pattern have recently found to be also expressed in medullary thymic epithelial cells (mTEC). This unique feature of mTEC plays an important role in preventing hazardous autoimmune responses through thymic tolerization of T-cell subsets directed against autoantigens but could also limit… CONTINUE READING