Expression of a multidrug resistance gene in human rheumatoid synovium

  title={Expression of a multidrug resistance gene in human rheumatoid synovium},
  author={Christian Jorgensen and Ronggai Sun and Jean François Rossi and J. Costes and Doriane G Richard and Carolina Bologna and Jacques Sany},
  journal={Rheumatology International},
The objective of this study was to assess the expression of a multidrug resistance (MDR) phenotype, implicated in the cellular resistance of tumor to chemotherapy, in rheumatoid synovial membrane. Synovial membrane from 16 rheumatoid (RA) patients was studied. Six patients with osteoarthritis constituted the control group. The cell membrane expression of the glycoprotein Pgp 170, encoded by the MDR 1 gene, was determined by an immunoperoxidase technique using two different monoclonal antibodies… CONTINUE READING