Expression of a mammalian DNA photolyase confers light-dependent repair activity and reduces mutations of UV-irradiated shuttle vectors in xeroderma pigmentosum cells.

@article{Asahina1999ExpressionOA,
  title={Expression of a mammalian DNA photolyase confers light-dependent repair activity and reduces mutations of UV-irradiated shuttle vectors in xeroderma pigmentosum cells.},
  author={H Asahina and Z Han and Masanobu Kawanishi and Taka-aki Kato and Hitoshi Ayaki and Takeshi Todo and Tomohito Yagi and Hiraku Takebe and Mituo Ikenaga and Shinya H Kimura},
  journal={Mutation research},
  year={1999},
  volume={435 3},
  pages={255-62}
}
Photoreactivation is one of the DNA repair mechanisms to remove UV lesions from cellular DNA with a function of the DNA photolyase and visible light. Two types of photolyase specific for cyclobutane pyrimidine dimers (CPD) and for pyrimidine (6-4) pyrimidones (6-4PD) are found in nature, but neither is present in cells from placental mammals. To investigate… CONTINUE READING