Expression of a lipid-inducible, self-regulating form of Yarrowia lipolytica lipase LIP2 in Saccharomyces cerevisiae

@article{Shockey2011ExpressionOA,
  title={Expression of a lipid-inducible, self-regulating form of Yarrowia lipolytica lipase LIP2 in Saccharomyces cerevisiae},
  author={Jay Shockey and Dorselyn C. Chapital and Satinder K Gidda and Catherine Mason and Gaynelle Davis and K. Thomas Klasson and Heping Cao and Robert Mullen and John Dyer},
  journal={Applied Microbiology and Biotechnology},
  year={2011},
  volume={92},
  pages={1207-1217}
}
Saccharomyces cerevisiae is frequently used as a bioreactor for conversion of exogenously acquired metabolites into value-added products, but has not been utilized for bioconversion of low-cost lipids such as triacylglycerols (TAGs) because the cells are typically unable to acquire these lipid substrates from the growth media. To help circumvent this limitation, the Yarrowia lipolytica lipase 2 (LIP2) gene was cloned into S. cerevisiae expression vectors and used to generate S. cerevisiae… CONTINUE READING
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