Expression of a human alpha-globin/fibronectin gene hybrid generates two mRNAs by alternative splicing.

@article{VibePedersen1984ExpressionOA,
  title={Expression of a human alpha-globin/fibronectin gene hybrid generates two mRNAs by alternative splicing.},
  author={K Vibe-Pedersen and Alberto R. Kornblihtt and Francisco E. Baralle},
  journal={The EMBO journal},
  year={1984},
  volume={3 11},
  pages={2511-6}
}
We have isolated genomic clones for human fibronectin (FN), by screening a human gene library with previously isolated FN cDNA clones. We have recently reported two different FN mRNAs, one of them containing an additional 270 nucleotide insert coding for a structural domain ED. Restriction mapping and DNA sequencing of the genomic clones show that the ED type III unit corresponds to exactly one exon in the gene, whilst the two flanking type III units are split in two exons at variable positions… CONTINUE READING

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