Expression of a functionally active gp91phox-containing neutrophil-type NAD(P)H oxidase in smooth muscle cells from human resistance arteries: regulation by angiotensin II.

@article{Touyz2002ExpressionOA,
  title={Expression of a functionally active gp91phox-containing neutrophil-type NAD(P)H oxidase in smooth muscle cells from human resistance arteries: regulation by angiotensin II.},
  author={Rhian M Touyz and Xin Chen and Fatiha Tabet and Guoying Yao and Gang He and Mark T Quinn and Patrick J Pagano and Ernesto L Schiffrin},
  journal={Circulation research},
  year={2002},
  volume={90 11},
  pages={
          1205-13
        }
}
A major source of vascular smooth muscle cell (VSMC) superoxide is NAD(P)H oxidase. However, the molecular characteristics and regulation of this enzyme are unclear. We investigated whether VSMCs from human resistance arteries (HVSMCs) possess a functionally active, angiotensin II (Ang II)-regulated NAD(P)H oxidase that contains neutrophil oxidase subunits, including p22phox, gp91phox, p40phox, p47phox, and p67phox. mRNA expression of gp91phox homologues, nox1 and nox4, was also assessed in… CONTINUE READING

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