Expression of a functional hyperpolarization-activated current (Ih) in the mouse nucleus reticularis thalami.

  title={Expression of a functional hyperpolarization-activated current (Ih) in the mouse nucleus reticularis thalami.},
  author={Yann Rateau and Nicole Ropert},
  journal={Journal of neurophysiology},
  volume={95 5},
The GABAergic neurons of the nucleus reticularis thalami (nRT) express the type 2 hyperpolarization-activated cAMP-sensitive (HCN2) subunit mRNA, but surprisingly, they were reported to lack the hyperpolarization-activated (Ih) current carried by this subunit. Using the voltage-clamp recordings in the thalamocortical slice preparation of the newborn and juvenile mice (P6-P23), we demonstrate that, in the presence of 1 mM barium (Ba2+), the nRT neurons express a slow hyperpolarization-activated… 

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