Expression of a functional hyperpolarization-activated current (Ih) in the mouse nucleus reticularis thalami.

@article{Rateau2006ExpressionOA,
  title={Expression of a functional hyperpolarization-activated current (Ih) in the mouse nucleus reticularis thalami.},
  author={Yann Rateau and Nicole Ropert},
  journal={Journal of neurophysiology},
  year={2006},
  volume={95 5},
  pages={
          3073-85
        }
}
The GABAergic neurons of the nucleus reticularis thalami (nRT) express the type 2 hyperpolarization-activated cAMP-sensitive (HCN2) subunit mRNA, but surprisingly, they were reported to lack the hyperpolarization-activated (Ih) current carried by this subunit. Using the voltage-clamp recordings in the thalamocortical slice preparation of the newborn and juvenile mice (P6-P23), we demonstrate that, in the presence of 1 mM barium (Ba2+), the nRT neurons express a slow hyperpolarization-activated… 
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Results indicate that Ih is carried by both Na+ and K+ ions, which is consistent with the extrapolated reversal potential of ‐43 mV, and contributes substantially to the resting and active membrane properties of thalamocortical relay neurones.

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The molecular cloning and functional expression of the gene encoding a hyperpolarization-activated cation channel (HAC1) that is present in brain and heart is reported, and this channel exhibits the general properties of Ih channels.

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