Expression of a foreign protein by influenza A virus.

@article{Percy1994ExpressionOA,
  title={Expression of a foreign protein by influenza A virus.},
  author={N S Percy and Wendy S Barclay and Adolfo Garc{\'i}a-Sastre and P. Palese},
  journal={Journal of virology},
  year={1994},
  volume={68 7},
  pages={
          4486-92
        }
}
In this report we describe the rescue of a transfectant influenza A virus which stably expresses a heterologous protein, bacterial chloramphenicol acetyltransferase (CAT). The foreign sequences encoding CAT are expressed as part of an essential influenza virus segment, that coding for the neuraminidase (NA) protein. The novel way by which this was achieved involved inserting in frame the 16-amino-acid self-cleaving 2A protease of foot-and-mouth disease virus between the CAT and the NA coding… CONTINUE READING

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