Expression of a drug resistance gene in human neuroblastoma cell lines: modulation by retinoic acid-induced differentiation.

@article{Bates1989ExpressionOA,
  title={Expression of a drug resistance gene in human neuroblastoma cell lines: modulation by retinoic acid-induced differentiation.},
  author={Susan E Bates and Lyn A Mickley and Y. N. Chen and Nancy D. Richert and Joyce Rudick and June L. Biedler and Antonio Tito Fojo},
  journal={Molecular and cellular biology},
  year={1989},
  volume={9 10},
  pages={4337-44}
}
Expression of a multidrug resistance gene (mdr1) and its protein product, P-glycoprotein (Pgp), has been correlated with the onset of multidrug resistance in vitro in human cell lines selected for resistance to chemotherapeutic agents derived from natural products. Expression of this gene has also been observed in normal tissues and human tumors, including neuroblastoma. We therefore examined total RNA prepared from human neuroblastoma cell lines before and after differentiation with retinoic… CONTINUE READING