Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in xenopus embryos

@article{Amaya1991ExpressionOA,
  title={Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in xenopus embryos},
  author={E. Amaya and T. Musci and M. Kirschner},
  journal={Cell},
  year={1991},
  volume={66},
  pages={257-270}
}
  • E. Amaya, T. Musci, M. Kirschner
  • Published 1991
  • Biology, Medicine
  • Cell
  • Peptide growth factors may play a role in patterning of the early embryo, particularly in the induction of mesoderm. We have explored the role of fibroblast growth factor (FGF) in early Xenopus development by expressing a dominant negative mutant form of the FGF receptor. Using a functional assay in frog oocytes, we found that a truncated form of the receptor effectively abolished wild-type receptor function. Explants from embryos expressing this dominant negative mutant failed to induce… CONTINUE READING

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