Expression of a dominant negative heat shock factor-1 construct inhibits aneuploidy in prostate carcinoma cells.

@article{Wang2004ExpressionOA,
  title={Expression of a dominant negative heat shock factor-1 construct inhibits aneuploidy in prostate carcinoma cells.},
  author={Yiqun Wang and Jimmy R. Th{\'e}riault and Haiying He and Jianlin Gong and Stuart K. Calderwood},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 31},
  pages={32651-9}
}
Recent studies have implicated heat shock proteins (HSP) and heat shock transcription factor 1 (HSF1) in tumor progression. We have examined the role of HSF1 in the malignant phenotype of PC-3 prostate carcinoma cells. We have developed a dominant negative construct of HSF1 that antagonizes transcription from HSP promoters and results in the depletion of intracellular HSP 70. Our studies indicate that expression of DN-HSF1 dramatically alters the DNA content of PC-3 cells (derived from p53 null… CONTINUE READING
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