Expression of a dominant negative TrkB receptor, T1, reveals a requirement for presynaptic signaling in BDNF-induced synaptic potentiation in cultured hippocampal neurons.

Abstract

We have developed a method to analyze the relative contributions of pre- and postsynaptic actions of a particular gene product in neurons in culture and potentially in slices using adenovirus-mediated gene transfer. A recombinant virus directed the expression of both a GFP reporter protein and TrkB.T1, a C-terminal truncated dominant negative TrkB… (More)

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@article{Li1998ExpressionOA, title={Expression of a dominant negative TrkB receptor, T1, reveals a requirement for presynaptic signaling in BDNF-induced synaptic potentiation in cultured hippocampal neurons.}, author={Y. X. Li and Y. Xu and D. Ju and Henry A. Lester and N. Davidson and Erin M Schuman}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1998}, volume={95 18}, pages={10884-9} }