Expression of a PKR dominant-negative mutant in myogenic cells interferes with the myogenic process.

Abstract

In this study, we explored the possibility that PKR, a dsRNA-activated regulatory protein, is an essential component in the differentiation program of myogenic cells in vitro. For this purpose, we used a retroviral expression vector pMV7, harboring the PKR dominant-negative mutant PKRDelta6 (pMV7-p68Delta6). Murine C2C12 myogenic cells were transfected… (More)

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@article{Salzberg2000ExpressionOA, title={Expression of a PKR dominant-negative mutant in myogenic cells interferes with the myogenic process.}, author={Steven L Salzberg and Shlomit Vilchik and S. Cohen and A. Heller and Y Kronfeld-Kinar}, journal={Experimental cell research}, year={2000}, volume={254 1}, pages={45-54} }