Expression of a G protein-coupled receptor (GPCR) leads to attenuation of signaling by other GPCRs: experimental evidence for a spontaneous GPCR constitutive inactive form.

Abstract

The idea of G protein-coupled receptors (GPCRs) coupling to G protein solely in their active form was abolished when it was found that certain ligands induce a G protein-coupled but inactive receptor form. This receptor form interferes with signaling of other receptors by sequestering G protein. However, the spontaneous existence of this receptor species… (More)
DOI: 10.1074/jbc.M109.099689

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Cite this paper

@article{Tubio2010ExpressionOA, title={Expression of a G protein-coupled receptor (GPCR) leads to attenuation of signaling by other GPCRs: experimental evidence for a spontaneous GPCR constitutive inactive form.}, author={Maria Rosario Tubio and Natalia Cristina Fern{\'a}ndez and Carlos P. Fitzsimons and Sabrina Copsel and S{\'e}rgio A. Santiago and Carina Shayo and Carlos A. Davio and Federico Monczor}, journal={The Journal of biological chemistry}, year={2010}, volume={285 20}, pages={14990-8} }