Expression of a Functional Chimeric 19 - Mhc Class I 1 Protein ' Jorg Zwirner , " Winfried Weissenhorn , ' Lars Karlsson , " Andrea Becker , " Per

Abstract

We have generated a chimeric protein molecule composed of the a-and B-chains of the MHC class I1 I-E molecule fused to antibody V regions derived from anti-human CD4 mAb MT310. Expression vectors were constructed containing the functional, rearranged gene segments coding for the V region domains of the antibody H and L chains in place of the first domains… (More)

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