Expression of a Cryptic Secondary Sigma Factor Gene Unveils Natural Competence for DNA Transformation in Staphylococcus aureus

@article{Morikawa2012ExpressionOA,
  title={Expression of a Cryptic Secondary Sigma Factor Gene Unveils Natural Competence for DNA Transformation in Staphylococcus aureus},
  author={K. Morikawa and Aya J. Takemura and Y. Inose and Melody Tsai and Le Thuy Nguyen Thi and T. Ohta and T. Msadek},
  journal={PLoS Pathogens},
  year={2012},
  volume={8}
}
It has long been a question whether Staphylococcus aureus, a major human pathogen, is able to develop natural competence for transformation by DNA. We previously showed that a novel staphylococcal secondary sigma factor, SigH, was a likely key component for competence development, but the corresponding gene appeared to be cryptic as its expression could not be detected during growth under standard laboratory conditions. Here, we have uncovered two distinct mechanisms allowing activation of SigH… Expand
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  • International journal of medical microbiology : IJMM
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