Expression of X-linked inhibitor of apoptosis protein in human prostate cancer specimens with and without neo-adjuvant hormonal therapy

@article{Watanabe2009ExpressionOX,
  title={Expression of X-linked inhibitor of apoptosis protein in human prostate cancer specimens with and without neo-adjuvant hormonal therapy},
  author={Shin‐ichi Watanabe and Y. Miyata and S. Kanda and T. Iwata and Tomayoshi Hayashi and H. Kanetake and H. Sakai},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={2009},
  volume={136},
  pages={787-793}
}
PurposeX-linked inhibitor of apoptosis (XIAP) has high affinity and strong inhibitory activity on apoptosis-related caspase-3. The relationships between expression of XIAP and cleaved caspase-3, and response to neo-adjuvant hormonal therapy (NHT) remain elusive. The aim was to investigate whether NHT influences with XIAP expression in prostate cancer patients. In addition, the relationship between XIAP expression and apoptosis in patients who did or did not receive NHT was also investigated… Expand
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References

SHOWING 1-10 OF 38 REFERENCES
Relationship between changes in prostate cancer cell proliferation, apoptotic index, and expression of apoptosis-related proteins by neoadjuvant hormonal therapy and duration of such treatment.
TLDR
The results support the current belief that the optimal duration of NHT is longer than 3 months and the expression of bcl-2 and bax increased in a manner parallel to that of the AI. Expand
Elevated expression of inhibitor of apoptosis proteins in prostate cancer.
TLDR
It is demonstrated that tumor- associated elevations in the expression of several IAP family proteins occur as a frequent and early event in the etiology of prostate cancer. Expand
Loss of caspase-1 and caspase-3 protein expression in human prostate cancer.
TLDR
The loss of caspase-1 protein is implicate as a potential step in the loss of apoptotic control during prostate tumorigenesis and is suggested to have prognostic significance in disease progression. Expand
Finasteride induces apoptosis via Bcl-2, Bcl-xL, Bax and caspase-3 proteins in LNCaP human prostate cancer cell line.
TLDR
It is suggested that finasteride induces apoptosis in LNCaP cells via proteins of the Bcl-2 and caspase family. Expand
Analysis of Apoptosis Protein Expression in Early-Stage Colorectal Cancer Suggests Opportunities for New Prognostic Biomarkers
TLDR
Immunohistochemical assays directed at detection of certain combinations of apoptosis proteins may provide prognostic information for patients with early-stage colorectal cancer, and therefore could help to identify patients who might benefit from adjuvant chemotherapy or who should be spared it. Expand
Loss of XIAP protein expression by RNAi and antisense approaches sensitizes cancer cells to functionally diverse chemotherapeutics
TLDR
Reducing XIAP protein expression by either RNAi or antisense approaches increases cancer cell susceptibility to functionally diverse chemotherapeutic agents and supports the notion that downregulation of XIAP in vivo may synergize with disease-relevant chemtherapeutic regimes, including TRAIL and taxanes, to increase the effectiveness of antineoplastic agents. Expand
Differential mechanisms of bicalutamide-induced apoptosis in prostate cell lines
TLDR
Understanding into how bicalutamide exerts its effects in androgen-independent cells will yield further insights into the treatment of hormone-refractory disease. Expand
Preclinical Characterization of AEG35156/GEM 640, a Second-Generation Antisense Oligonucleotide Targeting X-Linked Inhibitor of Apoptosis
TLDR
AEG35156 reduces XIAP levels and sensitizes tumors to chemotherapy and is presently under clinical assessment in multiple phase I trials in cancer patients as a single agent and in combination with docetaxel in solid tumors or cytarabine/idarubicin in leukemia. Expand
Cellular changes in prostate cancer cells induced by intermittent androgen suppression.
TLDR
The findings suggest that the long-term effect of androgen withdrawal on tumour growth is due to the inhibition of proliferation, suggesting that the biologic aggressiveness of a particular tumour is defined already at an early stage of disease. Expand
The inhibitors of apoptosis (IAPs) as cancer targets
TLDR
This review addresses IAP proteins as therapeutic targets for the treatment of cancer and emphasizes the importance of novel therapeutic approaches for cancer therapy. Expand
...
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3
4
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