Expression of Wilms tumor 1 gene in a variety of pediatric tumors.

@article{Oue2011ExpressionOW,
  title={Expression of Wilms tumor 1 gene in a variety of pediatric tumors.},
  author={Takaharu Oue and Shuichiro Uehara and Hiroaki Yamanaka and Yuichi Takama and Yusuke Oji and Masahiro Fukuzawa},
  journal={Journal of pediatric surgery},
  year={2011},
  volume={46 12},
  pages={
          2233-8
        }
}
BACKGROUND/PURPOSE Wilms tumor 1 (WT1) gene is overexpressed in many types of neoplasms, thus suggesting that WT1 has oncogenic properties. Therefore, WT1 is a molecular target for cancer therapy. The objectives of this study were to evaluate the WT1 gene expression in various pediatric tumors and to elucidate that WT1 can be a target of cancer therapy in pediatric malignancies. PATIENTS AND METHODS The expression of WT1 protein was examined in 60 cases of primary pediatric tumors. The levels… CONTINUE READING