Expression of WNT-5a and ROR2 correlates with disease severity in osteosarcoma

@inproceedings{Lu2012ExpressionOW,
  title={Expression of WNT-5a and ROR2 correlates with disease severity in osteosarcoma},
  author={Bei-ji Lu and Yingjie Wang and Xue-Jie Wei and Liang-Qun Rong and Dong Wei and Chang-Ming Yan and Deng-jie Wang and Jun-Ying Sun},
  booktitle={Molecular medicine reports},
  year={2012}
}
Osteosarcoma, a common malignancy primarily affecting children, generally has a poor prognosis. Novel diagnostic, prognostic and therapeutic markers are required to ameliorate the negative outcomes of this disease. We investigated two potential markers, WNT-5a and ROR2, which are hypothesized to dysregulate WNT signaling pathways to promote tumorigenesis in other types of cancer. We investigated WNT-5a and ROR2 expression using immunohistochemistry in 42 osteosarcoma and 12 osteochondroma… CONTINUE READING

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The progress of molecular diagnostics of osteosarcoma.

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