Expression of Vascular Endothelial Growth Factor and Its Receptor flk-1 in Soft Tissue Sarcomas: Correlation to Cathepsin Expression and Prognosis

@inproceedings{Wrl1998ExpressionOV,
  title={Expression of Vascular Endothelial Growth Factor and Its Receptor flk-1 in Soft Tissue Sarcomas: Correlation to Cathepsin Expression and Prognosis},
  author={Peter Uwe W{\"u}rl and Helge Taubert and Axel Meye and Dieter A. Berger and Christine Lautenschlaeger and Hannelore Schmidt and Raoul Hinze and F J Rath and Martin Sch{\"o}nfelder},
  year={1998}
}
Angiogenesis and decomposition of the extracellular matrix are essential suppositions for the growth of solid tumors. Cathepsins are a class of proteinases able to degradate extracellular matrix. They may have significance as a prognostic factor in soft tissue sarcomas (STS). Vascular endothelial growth factor (VEGF) is a specific endothelial cell mitogen and inducer of angiogenesis in normal as well as in tumor tissue. Little is known about VEGF and possible correlations to cathepsins in STS… CONTINUE READING

Similar Papers