Expression of V3 Versican by Rat Arterial Smooth Muscle Cells Promotes Differentiated and Anti-inflammatory Phenotypes.

@article{Kang2015ExpressionOV,
  title={Expression of V3 Versican by Rat Arterial Smooth Muscle Cells Promotes Differentiated and Anti-inflammatory Phenotypes.},
  author={Inkyung Kang and Jeremy L. Barth and Erin P Sproul and Dong Won Yoon and Gail A Workman and Kathleen R. Braun and W. Scott Argraves and Thomas N Wight},
  journal={The Journal of biological chemistry},
  year={2015},
  volume={290 35},
  pages={21629-41}
}
Arterial smooth muscle cells (ASMCs) undergo phenotypic changes during development and pathological processes in vivo and during cell culture in vitro. Our previous studies demonstrated that retrovirally mediated expression of the versican V3 splice variant (V3) by ASMCs retards cell proliferation and migration in vitro and reduces neointimal thickening and macrophage and lipid accumulation in animal models of vascular injury and atherosclerosis. However, the molecular pathways induced by V3… CONTINUE READING
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Expression of V3 Reprograms ASMC Phenotypes

  • K. Toeda, K. Nakamura, +7 authors Y. Ninomiya
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