Expression of Transient Receptor Potential Ankyrin 1 (TRPA1) and Its Role in Insulin Release from Rat Pancreatic Beta Cells

@inproceedings{Cao2012ExpressionOT,
  title={Expression of Transient Receptor Potential Ankyrin 1 (TRPA1) and Its Role in Insulin Release from Rat Pancreatic Beta Cells},
  author={De-Shou Cao and Linlin Zhong and Tsung-Han Hsieh and Mruvil Abooj and Mahendra Bishnoi and Lauren Hughes and Louis S. Premkumar},
  booktitle={PloS one},
  year={2012}
}
OBJECTIVE Several transient receptor potential (TRP) channels are expressed in pancreatic beta cells and have been proposed to be involved in insulin secretion. However, the endogenous ligands for these channels are far from clear. Here, we demonstrate the expression of the transient receptor potential ankyrin 1 (TRPA1) ion channel in the pancreatic beta cells and its role in insulin release. TRPA1 is an attractive candidate for inducing insulin release because it is calcium permeable and is… CONTINUE READING

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