Expression of Transcripts for Myelin Related Genes in Postmortem Brain from Cocaine Abusers

  title={Expression of Transcripts for Myelin Related Genes in Postmortem Brain from Cocaine Abusers},
  author={Lars V. Kristiansen and Michael J Bannon and James H. Meador-Woodruff},
  journal={Neurochemical Research},
Chronic abuse of cocaine is known to cause neuroadaptive changes in the nucleus accumbens (NAc) and ventral tegmental area (VTA). In addition, altered expression of the myelin-related genes MBP, MOBP, PLP1 as well as of MAL2 in NAc was recently reported by gene array analysis in brains from cocaine abusers. In the present study we used in situ hybridization to quantify transcript expression of these four genes, as well as for the myelin-related transcripts encoding quaking, EDG2, claudin-11… CONTINUE READING


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