Expression of Transcripts for Myelin Related Genes in Postmortem Brain from Cocaine Abusers

@article{Kristiansen2008ExpressionOT,
  title={Expression of Transcripts for Myelin Related Genes in Postmortem Brain from Cocaine Abusers},
  author={Lars V. Kristiansen and Michael J Bannon and James H. Meador-Woodruff},
  journal={Neurochemical Research},
  year={2008},
  volume={34},
  pages={46-54}
}
Chronic abuse of cocaine is known to cause neuroadaptive changes in the nucleus accumbens (NAc) and ventral tegmental area (VTA). In addition, altered expression of the myelin-related genes MBP, MOBP, PLP1 as well as of MAL2 in NAc was recently reported by gene array analysis in brains from cocaine abusers. In the present study we used in situ hybridization to quantify transcript expression of these four genes, as well as for the myelin-related transcripts encoding quaking, EDG2, claudin-11… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 70 references

Current concepts of PLP and its role in the nervous system.

Microscopy research and technique • 1998
View 4 Excerpts
Highly Influenced

from actions to habits to compulsion

BJ Everitt, Robbins TW Neural systems of reinforcement for drug addiction
Nat Neurosci 8:1481–1489 Fig. 3 Representative autoradiograms for Claudin 11 and PLP1 expression in matched control (a, c) and cocaine abusing subjects (b, d). a, b: Claudin 11 expression in dorsal caudate nucleus. c, d: PLP1 expression in striatum 52 Neurochem Res • 2009
View 2 Excerpts

statistical reliability and functional correlation

EM Blalock, KC Chen, Stromberg AJ et al Harnessing the power of gene microarrays aging, Alzheimer’s disease
Ageing Res Rev 4:481–512 54 Neurochem Res • 2009
View 1 Excerpt

Similar Papers

Loading similar papers…