Expression of TNF-alpha and Immunohistochemical Distribution of Hepatic Macrophage Surface Markers in Carbon Tetrachloride-induced Chronic Liver Injury in Rats

@article{Orfila1999ExpressionOT,
  title={Expression of TNF-alpha and Immunohistochemical Distribution of Hepatic Macrophage Surface Markers in Carbon Tetrachloride-induced Chronic Liver Injury in Rats},
  author={Claudine Orfila and J. C. Lepert and Laurent Alric and Georges Carrera and Maryse B{\'e}raud and Jean Pierre Vinel and Bernard Pipy},
  journal={The Histochemical Journal},
  year={1999},
  volume={31},
  pages={677-685}
}
In liver injury induced by carbon tetrachloride, secondary hepatic injury occurs from inflammatory processes originating from products released by activated Kupffer cells, which play a central role in hepatic inflammation. The purpose of our study was to demonstrate, in rats, the relationships between a function of the hepatic macrophages, TNF-α production and the state of activation of these cells, characterized by their phenotype, in the different phases of the process and development of… CONTINUE READING
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