Expression of TGF-β2 in LECs of age-related nuclear, cortex cataract and the relationship among TGF-β2, proliferation, apoptosis and transdifferentiation

@article{Lin2008ExpressionOT,
  title={Expression of TGF-β2 in LECs of age-related nuclear, cortex cataract and the relationship among TGF-β2, proliferation, apoptosis and transdifferentiation},
  author={Ye Lin and Cai Xiaojun and Zhang Baifang and Luo Hong and Deng Ping},
  journal={Wuhan University Journal of Natural Sciences},
  year={2008},
  volume={11},
  pages={756-760}
}
To detect the pathogenesis of age-related cataract, we analyzed the expression of TGF-β2 mRNA, proliferation cell nuclear antigen (PCNA), Bcl-2/Bax, fibronection (FN), vimentin protein and the density of lens epithelial cells(LECs) of nuclear cataract, cortex cataract and normal LECs. Results showed that the expression level of TGF-β2, mRNA, FN and vimentin protein was higher in LECs of cortex cataract than that of nuclear cataract and normal lens. But the level of Bcl-2/Bax and PCNA was on the… CONTINUE READING