Expression of TGFβ family factors and FGF2 in mouse and human embryonic stem cells maintained in different culture systems

@article{Lifantseva2013ExpressionOT,
  title={Expression of TGF$\beta$ family factors and FGF2 in mouse and human embryonic stem cells maintained in different culture systems},
  author={N. V. Lifantseva and A. M. Koltsova and Galina Poljanskaya and Olga Gordeeva},
  journal={Russian Journal of Developmental Biology},
  year={2013},
  volume={44},
  pages={7-18}
}
Mouse and human embryonic stem cells are in different states of pluripotency (naive/ground and primed states). Mechanisms of signaling regulation in cells with ground and primed states of pluripotency are considerably different. In order to understand the contribution of endogenous and exogenous factors in the maintenance of a metastable state of the cells in different phases of pluripotency, we examined the expression of TGFβ family factors (ActivinA, Nodal, Lefty1, TGFβ1, GDF3, BMP4) and FGF2… 

Low expression of activin a in mouse and human embryonic teratocarcinoma cells

  • O. Gordeeva
  • Biology
    Russian Journal of Developmental Biology
  • 2014
In mouse and human nullipotent teratocarcinoma cells, the expression of ActivinA is significantly reduced compared with embryonic stem cells, Presumably, these differences may be associated with changes in the functional activity of the respective signaling pathways and deregulation of proliferative and antiproliferative mechanisms in embryonic teratOCarcinomas cells.

TGFβ Family Signaling Pathways in Pluripotent and Teratocarcinoma Stem Cells’ Fate Decisions: Balancing Between Self-Renewal, Differentiation, and Cancer

This review summarizes recent advances in the understanding of TGFβ family functions in naїve and primed pluripotent stem cells and discusses how these pathways are involved in perturbations in the signaling network of malignant teratocarcinoma stem cells with impaired differentiation potential.

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