Expression of T-lineage-affiliated transcripts and TCR rearrangements in acute promyelocytic leukemia: implications for the cellular target of t(15;17).

@article{Chapiro2006ExpressionOT,
  title={Expression of T-lineage-affiliated transcripts and TCR rearrangements in acute promyelocytic leukemia: implications for the cellular target of t(15;17).},
  author={Elise Chapiro and Eric C M Delabesse and Vahid Asnafi and Corinne Millien and Frederic Davi and Elizabeth K. Nugent and Kheira Beldjord and Torsten Haferlach and David J Grimwade and Elizabeth A Macintyre},
  journal={Blood},
  year={2006},
  volume={108 10},
  pages={3484-93}
}
Acute promyelocytic leukemia (APL) is the most differentiated form of acute myeloid leukemia (AML) and has generally been considered to result from transformation of a committed myeloid progenitor. Paradoxically, APL has long been known to express the T-cell lymphoid marker, CD2. We searched for other parameters indicative of T-cell lymphoid specification in a cohort of 36 APL cases, revealing a frequent but asynchronous T-cell lymphoid program most marked in the hypogranular variant (M3v… CONTINUE READING

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