Expression of T-cell receptor alpha-chain genes in transgenic mice.


To examine the influences responsible for shaping the T-cell repertoire in vivo, we have introduced T-cell receptors of defined specificity into mice. In this report, we analyze transgenic mice carrying a T-cell receptor alpha-chain gene from a pigeon cytochrome c-reactive T-cell line. A variant of this construct, which has the immunoglobulin heavy-chain… (More)


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@article{Berg1988ExpressionOT, title={Expression of T-cell receptor alpha-chain genes in transgenic mice.}, author={Leslie J Berg and Barbara Fazekas de St Groth and Fredrik Ivars and Christopher C Goodnow and Stuart M. V. Gilfillan and Henri Jean Garchon and M. M. Davis}, journal={Molecular and cellular biology}, year={1988}, volume={8 12}, pages={5459-69} }