Expression of Sox2 in mouse taste buds and its relation to innervation

@article{Suzuki2008ExpressionOS,
  title={Expression of Sox2 in mouse taste buds and its relation to innervation},
  author={Yoshiyuki Suzuki},
  journal={Cell and Tissue Research},
  year={2008},
  volume={332},
  pages={393-401}
}
Sox2, which encodes an HMG box transcription factor, is known to regulate the differentiation of progenitor cells of the tongue into taste bud cells versus keratinocytes during development. To determine the neural dependence of Sox2 expression, glossopharyngeal nerves of mice were cut bilaterally. In unoperated mice, the expression of Sox2 mRNA and protein was restricted to a subset of taste bud cells and to the epithelium surrounding the taste buds of the circumvallate papillae. During the… CONTINUE READING
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