Expression of Sorsby's fundus dystrophy mutations in human retinal pigment epithelial cells reduces matrix metalloproteinase inhibition and may promote angiogenesis.

@article{Qi2002ExpressionOS,
  title={Expression of Sorsby's fundus dystrophy mutations in human retinal pigment epithelial cells reduces matrix metalloproteinase inhibition and may promote angiogenesis.},
  author={Jian Hua Qi and Quteba Ebrahem and Karen Yeow and Dylan R W Edwards and Paul L. Fox and Bela Anand-Apte},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 16},
  pages={13394-400}
}
Sorsby's fundus dystrophy (SFD) is an autosomal dominant degenerative disease of the macula caused by mutations in the tissue inhibitor of metalloproteinase-3 (TIMP-3) gene. Choroidal neovascularization is a hallmark of this disease, which closely resembles the exudative form of age-related macular degeneration. However, the mechanism by which TIMP-3 mutations induce the disease phenotype in SFD remains unknown. To address this question we established human retinal pigment epithelial cell lines… CONTINUE READING
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