Expression of Snail is associated with myofibroblast phenotype development in oral squamous cell carcinoma

  title={Expression of Snail is associated with myofibroblast phenotype development in oral squamous cell carcinoma},
  author={Marcus Franz and Karin Spiegel and Claudia Umbreit and Petra Richter and Carolina Codina-Canet and Angela Berndt and Annelore Katharina Altendorf-Hofmann and Sven Koscielny and Peter Hyckel and Hartwig Kosmehl and Ismo Virtanen and Alexander Berndt},
  journal={Histochemistry and Cell Biology},
Snail is a regulator of epithelial–mesenchymal transition (EMT) and considered crucial to carcinoma metastasis, myofibroblast transdifferentiation, and fibroblast activation. To investigate the role of Snail in oral squamous cell carcinoma (OSCC), its immunohistochemical expression was analysed in 129 OSCC samples and correlated to nodal metastasis, histological grade, E-cadherin, and alpha smooth-muscle-actin (αSMA). The results were compared to findings in 23 basal cell carcinomas (BCC… CONTINUE READING


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